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李敏

副研究员

电子邮件:limin2021@sjtu.edu.cn

通讯地址:科研楼1724室,上海交通大学医学院附属仁济医院

教育背景

  • 2013.09-2018.06     中国科学院上海应用物理研究所,化学,博士

  • 2009.09-2013.06     鲁东大学,化学,学士

工作经历

  • 2020.07~至今:上海交通大学医学院,副研究员

  • 2018.7~2020.6:上海交通大学医学院附属仁济医院,博士后

研究方向


  • 界面调控

  • 框架核酸液体活检;

  • 纳米电化学生物传感


科研项目

  • 国家自然科学基金委员会, 21904086,框架核酸组合探针界面精确调控及其在长片段ctDNA检测中的应用,主持;

  • 国家重点研发计划,2020YFA0909000,消化系统肿瘤高特异分子探针的创制与临床转化研究,骨干;

  • 国家重点研发计划,2021YFF1200300,基于大规模可寻址可控催化原理的 DNA 合成新技术研发,骨干。

代表性论文

  • Min Li#, Hongming Ding#, Meihua Lin#, Fangfei Yin, Lu Song, Xiuhai Mao, Fan Li, Zhilei Ge, Lihua Wang, Xiaolei Zuo,* Yuqiang Ma,* Chunhai Fan, DNA framework-programmed cell capture via topology-engineered receptor-ligand interactions. Journal of the American Chemical Society, 2019, 141, 18910-18915.

  • Min Li#, Fangfei Yin#, Lu Song#, Xiuhai Mao, Fan Li, Chunhai Fan, Xiaolei Zuo,* Qiang Xia,* Nucleic Acid Tests for Clinical Translation. Chemical Reviews, 2021, 121, 17, 10469-10558.

  • Fangfei Yin#, Min Li#, Xiuhao Mao, Fan Li, Xuelin Xiang, Qian Li, Lihua Wang, Xiaolei Zuo, Chunhai Fan, Ying Zhu,* DNA framework-based topological cell sorters. Angewandte Chemie International Edition, 2020, 59, 10406-10410

  • Dekai Ye#, Min Li#, Tingting Zhai#, Ping Song#, Lu Song, Hua Wang, Xiuhai Mao, Fei Wang, Xueli Zhang, Zhilei Ge, Jiye Shi, Lihua Wang, Chunhai Fan, Qian Li,* Xiaolei Zuo,* Encapsulation and release of living tumor cells using hydrogels with the hybridization chain reaction. Nature Protocols, 2020, 15, 2163-2185

  • Jiangbo Liu, Min Li,* Fan Li, Zhilei Ge, Qian Li, Mengmeng Liu, Jiye Shi, Lihua Wang, Xiaolei Zuo,* Chunhai Fan, Xiuhai Mao,* Reconstructing Soma-Soma Synapses-like Vesicular Exocytosis with DNA Origami, ACS Central Science, 2021, 7, 1400-1407

  • Haipei Zhao, Dekai Ye, Xiuhai Mao, Fan Li, Jiaqiang Xu,* Min Li,* Xiaolei Zuo, Stepping gating of ion channels on nanoelectrode via DNA hybridization for label-free DNA detection. Biosensors and Bioelectronics, 2019, 133, 141-146.

  • Lu Song, Ying Zhuge, Xiaolei Zuo, Min Li,* Fang Wang,* DNA Walkers for Biosensing Development. Advanced Science. 2022, 9, 202200327.

  • Min Li#, Xudong Guo#, Hui Li#, Xiaolei Zuo, Rongzhang Hao, Hongbin Song, Ali Aldalbahi, Zhilei Ge, Jiang Li, Qian Li, Shiping Song, Shaohua Li, Ningsheng Shao, Chunhai Fan,* Lihua Wang,* Epitope binning assay using an electron transfer-modulated aptamer sensor. ACS Applied Materials & Interfaces, 2018, 10, 341-349.

  • Min Li#, Min Lv, Lihua Wang, Chunhai Fan, Xiaolei Zuo,* Engineering electrochemical interface for biomolecular sensing. Current Opinion in Electrochemistry, 2019, 14, 71-80.

  • Min Li#, Bin Zhao#, Mengying Deng, Chenglie Lin, Yueyue Zhang, Yi Zhou, Jiye Shi, Lihua Wang, Xiaolei Zuo, Chunhai Fan, Qian Li,* Programming biosensing sensitivity by controlling the dimension of nanostructured electrode. Analytical and Bioanalytical Chemistry, 2019, 411, 4085-4092.

  • Min Li, Jiangbo Liu, Mengying Deng, Zhilei Ge, Noshin Afshan, Xiaolei Zuo,* Qian Li,* Rapid transmembrane transport of DNA nanostructures by chemically anchoring artificial receptors on cell membranes. ChemPlusChem, 2019, 84, 323-327.

  • Min Li, Jiangbo Liu, Haipei Zhao, Lu Song, Xiuhai Mao, Zhilei Ge, Qian Li, Fan Li,* Xiaolei Zuo,* DNA framework-programmed micro-nano hierarchy sensor interface for metabolite analysis in whole blood. ACS Applied Bio Materials, 2020, 3, 1, 53-58.

  • Mengying Deng#, Min Li#, Fan Li#, Xiuhai Mao, Qian Li, Jianlei Shen, Xiaolei Zuo,* Chunhai Fan,* Programming accessibility of DNA monolayers for degradation-free whole-blood biosensors. ACS Materials Letters, 2019, 1, 671-676.

  • Yueyue Zhang#, Fan Li#, Xiuhai Mao, Min Li,* Xiaolei Zuo,* Deformation-Resistant, Double-Layer DNA Self-Assembled Nanoraft with High Positioning Precision. ACS Applied Bio Materials, 2020, 3, 2610-2616.

  • Fangfei Yin#, Nan Cao#, Xuelin Xiang#, Hao Feng, Fan Li, Min Li,* Qiang Xia, Xiaolei Zuo, DNA Framework-Based Topological Aptamer for Differentiating Subtypes of Hepatocellular Carcinoma Cells. Chemical Research in Chinese Universities, 2021, 3, 919-924.

  • Jiangbo Liu, Yirong Chen, Fan Li, Xiuhai Mao, Min Li,* Xiaolei Zuo,* Chunhai Fan, Programming cell entry of molecules via reversible synthetic DNA circuits on cell membrane. Fundamental Research, 2021, 1, 747-751.

  • Yueyue Zhang, Jiangbo Liu, Xinxin Jing, Fan Li, Xiuhai Mao, Min Li,* Monitoring of Intracellular Vesicles in Cultured Neurons at Different Growth Stages Using Intracellular Vesicle Electrochemical Cytometry. Electroanalysis, 2021, 34, 202100343.

  • Ruiyan Guo, Min Li,* Xiaolei Zuo,* DNA Framework-Mediated Geometric Renormalization of Gold Nanoparticles. ChemPlusChem, 2021, 86, 10,1472–1475.