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曲倩

助理研究员

电子邮件:quqian22@sjtu.edu.cn

通讯地址:转化医学中心N410,上海交通大学闵行校区

教育背景

  • 2016.09-2021.06     清华大学,化学,博士

  • 2012.09-2016.06     合肥工业大学,制药工程,学士

工作经历

  • 2022.3~至今:上海交通大学转化医学研究院,助理研究员

  • 2021.11~2022.2:上海大学转化医学研究院,助理研究员

研究方向

  • 蛋白质化学合成方法学及应用转化

代表性论文

  • Yangwode Jing, Chong Zuo, Yun-Xiang Du, Junxiong Mao, et al, Qian Qu*. Chemical tools for E3 ubiquitin ligase study. Chinese Chem. Lett. 2022, https://doi.org/10.1016/j.cclet.2022.107781.

  • Lu-Jun Liang#, Guo-Chao Chu#, Qian Qu#, Chong Zuo, et al, Lei Liu*. Chemical synthesis of activity-based E2-ubiquitin probes for the structural analysis of E3 ligase-catalyzed transthiolation. Angew. Chem. Int. Ed. 2021, 60(31):17171-17177.

  • Jinrui Zhang#, Yao Sun#, Qian Qu#, Bo Li, Lili Zhang, et al, Hongjie Zhang*. Engineering non-covalently assembled protein nanoparticles for long-acting gouty arthritis therapy. J Mater Chem B. 2021; 9(48): 9923-9931.

  • Qian Qu#, Shuai Gao#, Fangming Wu#, Meng-Ge Zhang, et al, Lei Liu*. Synthesis of Disulfide Surrogate Peptides Incorporating Large-Span Surrogate Bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy. Angew. Chem. Int. Ed. 2020, 59, 6037-6045.

  • Qian Qu#, Man Pan#, Shuai Gao, Qing-Yun Zheng, et al, Hong-Gang Hu*. A Highly Effcient Synthesis of Polyubiquitin Chains. Adv. Sci. 2018, 5, 1800234.

  • Qian Qu, Shuai Gao, Yi‐Ming Li*. Racemic crystal structures of peptide toxins, GsMTx4 prepared by protein total synthesis. J. Pep. Sci. 2018, 24, e3112.

  • Shuai Gao#, William C. Valinsky#, Nguyen Cam On, Patrick R. Houlihan, Qian Qu, et al, Nieng Yan*. Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+ channels in nanodisc. Proc. Natl. Acad. Sci., 2020, 117(25), 14187-14193.

  • Yun-Kun Qi, Qian Qu, Donald Bierer, Lei Liu*. A Diaminodiacid (DADA) Strategy for the Development of Disulfide Surrogate Peptides. Chem. Asian J. 2020, 15, 1-11.

  • Man Pan#, Qingyun Zheng#, Shan Ding#, Lujia Zhang#, Qian Qu, et al, Lei Liu*. Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains. Angew. Chem. Int. Ed. 2019, 58, 2627-2631.

  • Huasong Ai, Yu Guo, Demeng Sun, Sanling Liu, Yunkun Qi, Jing Guo, Qian Qu, Qingyue Gong, et al, Lei Liu* Examination of the Deubiquitylation Site Selectivity of USP51 by Using Chemically Synthesized Ubiquitylated Histones. ChemBioChem. 2019, 20, 221-229.

  • Chen-Chen Chen#, Shuai Gao#, Hua-Song Ai, Qian Qu, Chang-Lin Tian& Yi-Ming Li*. Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis. Sci. China Chem. 2018, 61, 702-707.

  • Ling Xu#, Jian-Feng Huang#, Chen-Chen Chen, Qian Qu, Jing Shi, Man Pan, Yi-Ming Li*. Chemical Synthesis of Natural Polyubiquitin Chains through Auxiliary-Mediated Ligation of an Expressed Ubiquitin Isomer. Org Lett. 2018, 20(2), 329-332.

  • Chenchen Chen, Shuai Gao, Qian Qu, Pengcheng Mi, Anjin Tao, Yi-Ming Li*. Chemical synthesis and structural analysis of guanylate cyclase C agonist linaclotide. Chinese Chem. Lett. 2018, 29, 1135-1138.

  • Demeng Sun, You Yu, Xiaobin Xue, Man Pan, Ming Wen, Siyu Li, Qian Qu, Xiaorun Li, et al, Changlin Tian*. Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect. Cell Discov. 2018, 4, 27.