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沈琦

博士,长聘教轨副教授,博士生导师

电子邮件:qishen@sjtu.edu.cn

教育背景

  • 2007.09 - 2013.07 北京大学,前沿交叉学科研究院,理学博士

  • 2002.09 - 2006.07 南昌大学,生命科学学院,理学学士

工作经历

  • 2024年-至今 上海交通大学,化学化工学院,长聘教轨副教授

  • 2018.07 -2023.06 耶鲁大学,分子生物物理学与生物化学系,研究科学家

  • 2014.07 -2018.07 耶鲁大学,细胞生物学系,博士后

研究方向

  • 核酸与蛋白质纳米装置设计、组装与应用;

  • DNA纳米反应器设计与应用;

  • DNA纳米通道设计与应用

科研项目

  • 中组部国家海外高层次引进人才计划,2024-2026,主持

代表性论文专著

  • Q. Shen, Q. Feng, Q. Xiong, C. Wu, Y. Yuan, T. Tian, S. Yuan, J. Temple, C. Aiken, A.N. Engelman, C.P. Lusk, C. Lin, and Y. Xiong, "Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels",  Nature Structural & Molecular Biology, 2023, 30, 425-435.

  • P. Zhan, A. Peil, Q. Jiang, D. Wang, S. Mousavi, Q. Xiong, Q. Shen, Y. Shang, B. Ding, C. Lin, Y. Ke, and N. Liu. "Recent Advances in DNA Origami-Engineered Nanomaterials and Applications", Chemical Reviews, 2023, 123, 3976-4050

  • Q. Shen, S. Kumari, C. Xu, S. Jang, J. Shi, R.C. Burdick, L. Levintov, Q. Xiong, C. Wu, S.C. Devarkar, T. Tian, T.N. Therese, Y. Hu, S. Yuan, J. Temple, Q. Feng, P. Lusk, C. Aiken, A.N. Engelman, J. Perilla, V.K. Pathak, C. Lin, and Y. Xiong, "The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores", Proc Natl Acad Sci USA, 2023, 120, e2202815120.

  • W. Luo, V. Demidov, Q. Shen, H. Girão, M. Chakraborty, A. Maiorov, F. Ataullakhanov, C. Lin, H. Maiato, E. Grishchuk. "CLASP2 recognizes tubulins exposed at the microtubule plus-end in a nucleotide-state sensitive manner", Science Advances, 2023, 9, eabq5404.

  • Q. Shen#, Q. Xiong#, K. Zhou, Q. Feng, L. Liu, T. Tian, C. Wu, Y. Xiong, T.J. Melia, C.P. Lusk, and C. Lin, "Functionalized DNA-Origami-Protein Nanopores Generate Large Transmembrane Channels with Programmable Size-Selectivity", J Am Chem Soc, 2023, 145, 1292–1300.

  • Q. Shen, C. Wu, C. Freniere, T. N. Tripler, Y. Xiong. "Nuclear Import of HIV-1", Viruses, 2021, 13, 2242

  • Q. Shen, T. Tian, Q. Xiong, P.D.E. Fisher, Y. Xiong, T.J. Melia, C.P. Lusk, and C. Lin, "DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins", J Am Chem Soc, 2021, 143, 12294-12303.

  • Q. Shen and C. Lin. "RNA returns to the fold", Nature Chemistry, 2020, 12, 221-222.

  • Y. Hu, K. Knecht, Q. Shen, Y. Xiong, "Multifaceted HIV-1 Vif interactions with Human E3 Ubiquitin Ligase and APOBEC3s". FEBS J., 2020, 288, 3407-3417.

  • S. Yuan, L Peng, J. J. Park, Y. Hu, S. C. Devarkar, M. B. Dong, Q. Shen, S. Wu, S. Chen, I. B. Lomakin, and Y. Xiong. "Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA",  Molecular Cell, 2020, 80, 1-12.

  • Q. Xiong, C. Xie, Z. Zhang, L. Liu, J. Powell, Q. Shen, and C. Lin, "DNA Origami Post-Processing by CRISPR-Cas12a", Angew Chem Int. Edit, 2020, 59, 3956-3960.

  • J. Temple#, T.N. Tripler#, Q. Shen#, Y. Xiong. "A snapshot of HIV-1 capsid–host interactions", Curr Res Struct Biol, 2020, 2, 222-228.

  • Q. Shen, M.W. Grome, Y. Yang, and C. Lin. "Engineering Lipid Membranes with Programmable DNA Nanostructures", Adv Biosyst, 2020, 4, 1900215.

  • P. Fisher#Q. Shen#, B. Akpinar, L. Davis, K. Chung, D. Baddeley, A. Šarić, T. Melia, B. Hoogenboom, C. Lin, and P. Lusk. "A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement", ACS Nano, 2018, 2, 1508-1518.

  • Q. Shen#, C. Zhang#, J. Cao, Y. Liu, Y. Liang, M. Zhao, and L. Lai. "De novo design of helical peptides to inhibit TNFα by disrupting its trimer formation", MedChemComm, 2016, 7, 725-729.

  • Q. Shen#, J. Chen#, Q. Wang, X. Deng, and L. Lai. "Discovery of highly potent TNFα inhibitors using virtual screening", Eur J Med Chem, 2014, 65, 119-126.

  • G. Stanley, B. Akpinar, Q. Shen, PDE. Fisher, C.P. Lusk, C. Lin, and B. Hoogenboom, "Quantification of Biomolecular Dynamics Inside Real and Synthetic Nuclear Pore Complexes Using Time-Resolved Atomic Force Microscopy", ACS Nano, 2019, 13, 7949-7956.

  • C. Zhang#Q. Shen#, B. Tang, and L. Lai. "Computational design of helical peptides targeting TNFα", Angew Chem Int Edit, 2013, 52, 11059-11062.