教育背景

• 2011-2016     普渡大学，化学系，博士

• 2003-2006    清华大学，化学系，硕士

• 1999-2003     清华大学，化学系，学士

工作经历

• 2020~ : 上海交通大学化学化工学院，长聘副教授

• 2014~2020：上海交通大学化学化工学院，特别研究员

• 2011~2014：美国西北大学化学系，博士后

研究方向

• 核酸修饰和新型核酸药物开发

• 核酸递送和基因治疗

科研项目

• 国家自然科学基金杰出青年科学基金，52225302，核酸药物递送系统，2023-2027，立项，主持；

• 国家自然科学基金面上项目，51973112，硫代寡核苷酸-药物偶联物的合成、组装及其应用研究，2020-2023，在研，主持；

• 科技部国家重点研发计划，2018YFA0902601，使用合成 DNA 进行数据存储的技术研发，2019-2024，在研，参与；

• 科技部国家重点研发计划课题，2018YFC1106100，新型高分子眼科功能性植入材料的研发和应用，2018-2022，结题中，子课题负责人；

• 国家自然科学基金国际(地区)合作与交流项目（中港合作基金），21661162001，自组装DNA纳米结构高效基因载体的构建及其与细胞的相互作用，2017-2020，已结题，主持；

• 国家自然科学基金面上项目，21673139，DNA诱导新型纳米粒子超晶格材料组装及其性能研究，2017-2020，已结题，主持；

• 国家自然科学基金重大研究计划集成项目，91527304，初级组装体的模块化组装、功能集成与仿生应用，2016-2018，已结题，参与；

• 国家自然科学基金青年基金，21504053，高密度核酸-聚酯胶束亲和杂化递送基因药物研究，2016-2018，已结题，主持；

• 国家高层次人才计划青年项目，DNA纳米技术及其生物医学应用，2015-2017,已结题，主持。

代表性论文

独立PI期间

• Yuanyuan Guo, Qiushuang Zhang, Qiwen Zhu, Jing Gao, Xinyuan Zhu, Haijun Yu*, Yuehua Li*, Chuan Zhang*, “Co-packaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy”, Sci. Adv., 2022, 8, eabn2941.

• Lijuan Zhu, Jiapei Yang, Yuan Ma, Xinyuan Zhu, Chuan Zhang*, “Aptamers Entirely Built from Therapeutic Nucleoside Analogues for Targeted Cancer Therapy”, J. Am. Chem. Soc., 2022, 144, 1493-1497.

• Xihui Gao, Sha Li, Fei Ding, Xinlong Liu, Yijing Wu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Virus-Mimicking Nucleic Acid Nanogel Reprograms the Microglia and Macrophage for Glioblastoma Therapy”, Adv. Mater., 2021, 33, 2006116.

• Lijuan Zhu, Yuanyuan Guo, Qiuhui Qian, Deyue Yan, Yuehua Li, Xinyuan Zhu, Chuan Zhang*, “Carrier-Free Delivery of Precise Drug-Chemogene Conjugates for Synergistic Treatment of Drug-Resistant Cancer”, Angew. Chem. Int. Ed., 2020, 59, 17944-17950.

• Huan Ge, Dongya Wang, Yue Pan, Yuanyuan Guo, Hongyu Li, Fan Zhang, Xinyuan Zhu, Yuehua Li, Chuan Zhang*, Ling Huang*, “Sequence-Dependent DNA Functionalization of Upconversion Nanoparticles and Their Programmable Assemblies”, Angew. Chem. Int. Ed., 2020, 59, 8133-8137.

• Jiao Zhang, Yuanyuan Guo, Fei Ding, Gaifang Pan, Xinyuan Zhu, and Chuan Zhang*, “Camptothecin-Grafted DNA Tetrahedron as Precise Nanomedicine to Inhibit the Tumor Growth”, Angew. Chem. Int. Ed., 2019, 58, 13794-13798.

• Xihui Gao, Sha Li, Fei Ding, Hongjia Fan, Leilei Shi, Lijuan Zhu, Jing Li, Jing Feng*, Xinyuan Zhu, Chuan Zhang*, “Rapid Detection of Exosomal microRNAs Using Virus-Mimicking Fusogenic Vesicles”, Angew. Chem. Int. Ed., 2019, 58, 8719-8723.

• Quanbing Mou, Yuan Ma, Fei Ding, Xihui Gao, Deyue Yan, Xinyuan Zhu, Chuan Zhang*, “Two-in-One Chemogene Assembled from Drug-Integrated Antisense Oligonucleotides to Reverse Chemoresistance”, J. Am. Chem. Soc., 2019, 141, 6955-6966.

• Yuanyuan Guo, Jiao Zhang, Fei Ding, Gaifang Pan, Jing Li, Jing Feng, Xinyuan Zhu, Chuan Zhang*, “Stressing the Role of DNA as Drug Carrier: Synthesis of the DNA-Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides”, Adv. Mater., 2019, 31, 1807533.

• Fei Ding, Quanbing Mou, Yuan Ma, Gaifang Pan, Yuanyuan Guo, Gangsheng Tong, Chung Hang Jonathan Choi, Xinyuan Zhu, Chuan Zhang*, “Crosslinked Nucleic Acid Nanogel for Effective siRNA Delivery and Antitumor Therapy”, Angew. Chem. Int. Ed., 2018, 57, 3064-3068.

博士-博后期间

• Chuan Zhang, Xiang Li, Cheng Tian, Guimei Yu, Yulin Li, Wen Jiang, Chengde Mao*, “DNA Nanocages Swallow Gold Nanoparticles (AuNPs) to Form AuNP@DNA Cage Core-Shell Structures”, ACS Nano, 2014, 8, 1130-1135.

• Chuan Zhang, Robert J Macfarlane, Kaylie L Young, Chung Hang J Choi, Liangliang Hao, Evelyn Auyeung, Guoliang Liu, Xiaozhu Zhou, Chad A Mirkin*, “A General Approach to DNA-Programmable Atom Equivalents”, Nat. Mater., 2013, 12, 741-746.

• Chuan Zhang, Cheng Tian, Xiang Li, Hang Qian, Chenhui Hao, Wen Jiang, Chengde Mao*, “Reversibly Switching the Surface Porosity of a DNA Tetrahedron”, J. Am. Chem. Soc., 2012, 134, 11998-12001.

• Chuan Zhang, Weimin Wu, Xiang Li, Cheng Tian, Hang Qian, Guan song Wang, Wen Jiang, Chengde Mao*, “Controlling the Chirality of DNA Nanocages”, Angew. Chem. Int. Ed., 2012, 51, 7999-8002.

• Chuan Zhang, Cheng Tian, Fei Guo, Zheng Liu, Wen Jiang, Chengde Mao*, “DNA-Directed Three Dimensional (3D) Protein Organization”, Angew. Chem. Int. Ed., 2012, 51, 3382-3385.

• Chuan Zhang, Chengde Mao*, “DNA Nanotechnology: Bacteria as factories”, Nat. Nanotech., 2008, 3, 707-708.

• Chuan Zhang, Min Su, Yu He, Xin Zhao, Ping-an Fang, Alexander E Ribbe, Wen Jiang, Chengde Mao*, “Conformational Flexibility Facilitates Self-Assembly of Complex DNA Nanostructures”, Proc. Natl. Acad. Sci. USA, 2008, 105, 10665-10669.