凌代舜
博士,教授,博士生导师
电子邮件:dsling@sjtu.edu.cn
通讯地址:转化医学研究院E350,上海交通大学闵行校区
教育背景
2009.09-2013.08 首尔大学,化学生物工学
2007.09-2009.08 东国大学,化学工学,硕士,
工作经历
2020.12~:上海交通大学变革性分子前沿科学中心/化学化工学院,教授
2014.12~2021.07:浙江大学药学院/生物医学工程学院,研究员/教授
2013.09~2014.12:韩国基础科学研究院纳米粒子研究团队,研究员
研究方向
化学生物学、生物材料;
纳米生物材料的制备与应用;
科研项目
上海市科学技术委员会,“科技创新行动计划”优秀学术带头人计划项目,21XD1422100,自组装生物材料,2021-2024,主持;
科技部重点研发计划“纳米科技”重点专项项目,2016YFA0203600,肿瘤微环境响应型磁性纳米粒子组装用于肝癌的可视化治疗,2016-2021,主持,已结题;
国自然基金委重大研究计划,91859116,多模态诊疗一体化纳米探针用于HER-2阳性乳腺癌转移灶受体定量、成像监测与克服耐药的研究,2019-2021,主持,已结题;
国自然基金委优秀青年科学基金项目,31822019,纳米递送系统,2019-2021,主持,已结题;
国自然基金委国际(地区)合作与交流项目,81761148029,基于分子影像的细胞治疗基础研究,2017-2022,参与,已结题;
浙江省科学技术厅,浙江省“一带一路”国际科技合作项目,2019C04024,浙江-韩国(浙大)磁性纳米医学造影剂国际联合实验室,2019-2022,主持,已结题;
国自然基金委青年科学基金项目,51503180,光敏剂高分子/氧化铁纳米粒复合材料用于干细胞基因传递和示踪,2016-2018,主持,已结题;
国自然基金委国际(地区)合作与交流项目,51611540345,有机高分子/无机纳米复合材料用于可视化干细胞基因治疗,2016-2018,主持,已结题。
代表性论文
Jianan Liu#; Fangyuan Li#; Yi Wang#; Limin Pan#; Peihua Lin; Bo Zhang; Yanrong Zheng; Yingwei Xu; Hongwei Liao; Giho Ko; Fan Fei; Cenglin Xu; Yang Du; Kwangsoo Shin; Dokyoon Kim; Sung-Soo Jang; Hee Jung Chung; He Tian; Qi Wang; Wei Guo; Jwa-Min Nam; Zhong Chen*; Taeghwan Hyeon*; Daishun Ling*. “A Sensitive and Specific Nanosensor for Monitoring Extracellular Potassium Levels in the Brain.” Nature Nanotechnology 2020, 15, 321-330.
Qinjie Weng#; Heng Sun#; Chunyan Fang#; Fan Xia; Hongwei Liao; Jiyoung Lee; Jincheng Wang; An Xie; Jiafeng Ren; Xia Guo; Fangyuan Li; Bo Yang; Daishun Ling*. “Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics.” Nature Communications 2021, 12(1), 1436.
Zeyu Liang#; Qiyue Wang#; Hongwei Liao#; Meng Zhao; Jiyoung Lee; Chuang Yang; Fangyuan Li; Daishun Ling*. “Artificially engineered antiferromagnetic nanoprobes for ultra-sensitive histopathological level magnetic resonance imaging.” Nature Communications 2021, 12(1), 3840.
Lingxiao Zhang#; Jing Zhao#; Xi Hu#; Chenhan Wang#; Yingbo Jia; Chaojie Zhu; Shangzhi Xie; Jiyoung Lee; Fangyuan Li*; Daishun Ling*. “A Peritumorally Injected Immunomodulating Adjuvant Elicits Robust and Safe Metalloimmunotherapy Against Solid Tumors.” Advanced Materials 2022, 2206915.
Jin Wang#; Yinhang Jia#; Qiyue Wang#; Zeyu Liang#; Guangxu Han; Zejun Wang; Jiyoung Lee; Meng Zhao; Fangyuan Li; Ruiliang Bai*; Daishun Ling*. “An Ultra-High Field-Tailored T1-T2 Dual-Mode MRI Contrast Agent for High-Performance Vascular Imaging.” Advanced Materials 2020, 3(2), 2004917.
Xi Hu#; Fangyuan Li#; Fan Xia#; Xia Guo; Nan Wang; Lili Liang; Bo Yang; Kelong Fan; Xiyun Yan; Daishun Ling*. “Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy.” Journal of American Chemical Society 2020, 142(3), 1636-1644.
Qiyue Wang#; Fangyuan Li#*; Zeyu Liang; Hongwei Liao; Bo Zhang; Peihua Lin; Xun Liu; Shen Hu; Jiyoung Lee; Daishun Ling*. “A K+-sensitive AND-gate dual-mode imaging probe for simultaneous tumor imaging and malignancy identification.” National Science Review 2022, 9(7), nwac080.
Fangyuan Li#; Yang Du#; Jianan Liu#; Heng Sun; Jin Wang; Ruiqing Li; Dokyoon Kim; Taeghwan Hyeon; Daishun Ling*. “Responsive Assembly of Upconversion Nanoparticles for pH-Activated and Near-Infrared-Triggered Photodynamic Therapy of Deep Tumors.” Advanced Materials 2018, 1802808.
Jingxiong Lu; Jihong Sun; Fangyuan Li; Jin Wang; Jianan Liu; Dokyoon Kim; Chunhai Fan; Taeghwan Hyeon; Daishun Ling*. “Highly Sensitive Diagnosis of Small Hepatocellular Carcinoma Using pH-Responsive Iron Oxide Nanocluster Assemblie.” Journal of American Chemical Society 2018, 140(32), 10071-10074.
Fangyuan Li; Jingxiong Lu; Xueqian Kong; Taeghwan Hyeon; Daishun Ling*. “Dynamic Nanoparticle Assemblies for Biomedical Applications.” Advanced Materials 2017, 29(14), 1605897.