李富友
博士,教授,博士生导师
电子邮件:lifuyou@sjtu.edu.cn
通讯地址:转化医学研究院C302,上海交通大学闵行校区
教育背景
1995-2000:北京师范大学,化学,博士
1991-1995:北京师范大学,化学,学士
工作经历
2022~至今:上海交通大学化学化工学院,教授
2006~2022:复旦大学化学系,教授
2003~2006:复旦大学化学系,副教授
2002~2003:北京大学化学与分子工程学院,讲师、副教授
2000~2002:北京大学化学与分子工程学院,博士后
研究方向
主要从事稀土生物医用研究,内容涉及:
活体发光定量成像
体外自测与病理诊断技术
光子器械引导个性化治疗
科研项目
国家自然科学基金重点项目,活体水平的时间分辨生物成像与检测技术,21937003,2020-2024,主持。
科技部国家重点研发计划纳米科技重点专项,基于稀土发光纳米技术的病原体检测研究,2017YFA0205100,2017-2022,主持。
国家自然科学基金面上项目,稀土发光纳米材料用于多通道体外检测, 21874027,2019-2022,主持。
代表性论文
Xianlong Su, Xiaoyan Kong, Kuangshi Sun, Qian Liu, Yuetian Pei, Donghao Hu, Ming Xu*, Wei Feng and Fuyou Li*, Enhanced Blue Afterglow through Molecular Fusion for Bio‐applications, Angew. Chem. Int. Ed. 2022, e202201630.
Sidi Zhang, Zhenhua Li, Qingbing Wang*, Qian Liu, Wei Yuan*, Wei Feng and Fuyou Li*, An NIR‐II Photothermally Triggered “Oxygen Bomb” for Hypoxic Tumor Programmed Cascade Therapy, Adv. Mater. 2022, 34, 2201978.
Na Wu, Yishuo Sun, Mengya Kong, Xue Lin, Cong Cao, Zhanxian Li, Wei Feng* and Fuyou Li*, Er‐Based Luminescent Nanothermometer to Explore the Real‐Time Temperature of Cells under External Stimuli, Small, 2022, 18, 2107963.
Yuxin Liu, Xingjun Zhu, Zheng Wei, Wei Feng, Luoyuan Li, Liyi Ma, Fuyou Li,* and Jing Zhou*, Customized Photothermal Therapy of Subcutaneous Orthotopic Cancer by Multichannel Luminescent Nanocomposites, Adv. Mater. 2021, 33, 2008615.
Ming Xu, Jia Liu, Xianlong Su, Qianwen Zhou, Hang Yuan, Yue Wen, Yihang Cheng, Fuyou Li*, Lanthanide-containing persistent luminescence materials with superbright red afterglow and excellent solution processability, Science China Chemistry, 2021, 64, 2125-2133.
Xiaochen Qiu, Qianwen Zhou, Xingjun Zhu, Zugen Wu, Wei Feng*, Fuyou Li*, Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique, Nat. Commun., 2020, 11, 4.
Yuyang Gu, Zhiyong Guo, Wei Yuan, Mengya Kong, Yulai Liu, Yongtao Liu, Yilin Gao, Wei Feng*, Fan Wang, Jiajia Zhou, Dayong Jin*, Fuyou Li*, High-sensitivity imaging of time-domain near-infrared light transducer, Nat. Photon., 2019, 13, 525.
Shengming Cheng, Bin Shen, Wei Yuan, Xiaobo Zhou, Qingyun Liu, Mengya Kong, Yibing Shi, Pengyuan Yang, Wei Feng*, and Fuyou Li*, Time-Gated Ratiometric Detection with the Same Working Wavelength to Minimize the Interferences from Photon Attenuation for Accurate in Vivo Detection, ACS Central Sci., 2019, 5, 299.
Ming Xu, Xianmei Zou, Qianqian Su, Wei Yuan, Cong Cao, Qiuhong Wang, Xingjun Zhu, Wei Feng*, Fuyou Li*, Ratiometric Nanothermometer in Vivo Based on Triplet-Sensitized Upconversion, Nat. Commun., 2018, 9,2698.
Xingjun Zhu, Jiachang Li, Xiaochen Qiu, Yi Liu, Wei Feng*, Fuyou Li*, Upconversion Nanocomposite for Programming Combination Cancer Therapy by Precise Control of Microscopic Temperature, Nat. Commun., 2018, 9, 2176
Jihye Park, Ming Xu, Fuyou Li*, Hong-Cai Zhou*, 3D Long-Range Triplet Migration in a Water-Stable Metal–Organic Framework for Upconversion-Based Ultralow-Power in Vivo Imaging, J. Am. Chem. Soc., 2018, 140, 5493-5499.
Xingjun Zhu§, Wei Feng§, Jian Chang, Yan-Wen Tan, Jiachang Li, Min Chen, Yun Sun & Fuyou Li*, Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature, Nat. Commun., 2016, 7, 10437.
Yi Liu, Qianqian Su, Min Chen, Yi Dong, Yibing Shi, Wei Feng, Zhi-Ying Wu, Fuyou Li*, Near-Infrared Upconversion Chemodosimeter for in Vivo Detection of Cu2+ in Wilson Disease, Adv. Mater., 2016. 28, 6625–6630.
Yuhao Li, YunSun, Jiachang Li, Qianqian Su, Wei Yuan, Yu Dai, Chunmiao Han, Qiuhong Wang, Wei Feng*, Fuyou Li *, Ultrasensitive Near-Infrared Fluorescence-Enhanced Probe for In Vivo Nitroreductase Imaging, J. Am. Chem. Soc., 2015, 137 (19), 6407–6416.
Jing Zhou, Qian Liu, Wei Feng, Yun Sun, Fuyou Li*, Upconversion Luminescent Materials: Advances and Applications, Chem. Rev., 2015, 115, 395−465.
Qian Liu, Wei Feng, Tianshe Yang, Tao Yi, Fuyou Li*, Upconversion Luminescence imaging of cells and small-animals, Nat. Protoc., 2013, 8(10), 2033-2044.
Yuming Yang, Qiang Zhao, Wei Feng, Fuyou Li*, Luminescent Chemodosimeters for Bioimaging, Chem. Rev., 2013, 113, 192-270.
Wei Feng, Chunmiao Han, Fuyou Li*, Upconversion-Nanophosphor-Based Functional Nanocomposites, Adv. Mater., 2013, 25(37), 5287–5303.
Zhen Jiang,| Ming Xu,| Fuyou Li*, Yanlei Yu*, Red-light Controllable Liquid-Crystal Soft Actuators via Low-power Excited Upconversion Based on Triplet-Triplet Annihilation, J. Am. Chem. Soc., 2013, 135, 16446-16453.
Yi Liu, Min Chen, Tianye Cao, Yun Sun, Chunyan Li, Qian Liu, Tianshe Yang, Liming Yao, Wei Feng, Fuyou Li*, A Cyanine-modified Nanosystem for in vivo Upconversion Luminescence Bioimaging of Methylmercury, J. Am. Chem. Soc., 2013, 135, 9869-9876.
Qian Liu, Baoru Yin, Tianshe Yang, Yongchao Yang, Zhen Shen, Ping Yao, Fuyou Li*, A general strategy for biocompatible, high-effective upconversion nanocapsules based on triplet-triplet annihilation, J. Am. Chem. Soc., 2013, 135, 5029–5037.
Yun Sun, Xingjun Zhu, Juanjuan Peng, Fuyou Li*, Core-shell lanthanide upconversion nanophorsphors as four-modal probes for tumor angiogenesis imaging, ACS Nano, 2013, 7 (12), 11290–11300.
Qian Liu, Tianshe Yang, Wei Feng, Fuyou Li*, Blue-emissive upconversion nanoparticles for low-power-excited bioimaging in vivo, J. Am. Chem. Soc., 2012, 134 (11), 5390–5397.
Chunyan Li, Mengxiao Yu, Yun Sun, Yongquan Wu, Chunhui Huang, Fuyou Li*, A Nonemissive Iridium(III) Complex That Specifically Lights-up the Nuclei of Living Cells, J. Am. Chem. Soc., 2011, 133, 11231–11239.
Jinliang Liu, Yi Liu, Qian Liu, Chunyan, Li, Lining Sun, Fuyou Li*, Iridium(III) Complex-Coated Nanosystem for Ratiometric Upconversion Luminescence Bioimaging of Cyanide Anions J. Am. Chem. Soc., 2011, 133, 15276–15279.
Wei Wu, Liming Yao, Tianshe Yang, Ruoyuan Yin, Fuyou Li*, Yanlei Yu*, NIR-Light-Induced Deformation of Cross-Linked Liquid-Crystal Polymers Using Upconversion Nanophosphors, J. Am. Chem. Soc., 2011, 133, 15810–15813.
Qian Liu, Yun Sun, Tianshe Yang, Wei Feng, Chenguang Li, Fuyou Li*, Sub-10 nm hexagonal lanthanide-doped NaLuF4 upconversion nanocyrstals for super-sensitive bioimaging in vivo, J. Am. Chem. Soc., 2011, 133, 17122–17125.
Mengxiao Yu, Fuyou Li,* Zhigang Chen, He Hu, Cheng Zhan, Hong Yang, Chunhui Huang, Laser Scanning Up-Conversion Luminescence Microscopy for Imaging Cells Labeled with Rare-Earth Nanophosphors, Anal. Chem., 2009, 81(3), 930–935.
Zhigang Chen, Huili Chen, He Hu, Mengxiao Yu, Fuyou Li,* Qiang Zhang, Zhiguo Zhou, Tao Yi, Chunhui Huang*, Versatile Synthesis Strategy for Carboxylic Acid-functionalized Upconverting Nanophosphors as Biological Labels, J. Am. Chem. Soc., 2008, 130, 3023-3029.
Meng Zhang, Mengxiao Yu, Fuyou Li,* Minwei Zhu, Menyu Li, Yanhong Gao, Lei Li, Zhiqiang Liu, Jianping Zhang, Dengqing Zhang, Tao Yi, Chunhui Huang*, A Highly Selective Fluorescence Turn-on Sensor for Cysteine/Homocysteine and Its Application in Bioimaging, J. Am. Chem. Soc., 2007, 129, 10322-10323.