李富友

博士,教授,博士生导师

电子邮件:lifuyou@sjtu.edu.cn

通讯地址:转化医学研究院C302,上海交通大学闵行校区

教育背景

  • 1995-2000:北京师范大学,化学,博士

  • 1991-1995:北京师范大学,化学,学士

工作经历

  • 2022~至今:上海交通大学化学化工学院,教授

  • 2006~2022:复旦大学化学系,教授

  • 2003~2006:复旦大学化学系,副教授

  • 2002~2003:北京大学化学与分子工程学院,讲师、副教授

  • 2000~2002:北京大学化学与分子工程学院,博士后

研究方向

主要从事稀土生物医用研究,内容涉及:

  • 活体发光定量成像

  • 体外自测与病理诊断技术

  • 光子器械引导个性化治疗

科研项目

  • 国家自然科学基金重点项目,活体水平的时间分辨生物成像与检测技术,21937003,2020-2024,主持。

  • 科技部国家重点研发计划纳米科技重点专项,基于稀土发光纳米技术的病原体检测研究,2017YFA0205100,2017-2022,主持。

  • 国家自然科学基金面上项目,稀土发光纳米材料用于多通道体外检测, 21874027,2019-2022,主持。

代表性论文

  • Xianlong Su, Xiaoyan Kong, Kuangshi Sun, Qian Liu, Yuetian Pei, Donghao Hu, Ming Xu*, Wei Feng and Fuyou Li*, Enhanced Blue Afterglow through Molecular Fusion for Bio‐applications, Angew. Chem. Int. Ed. 2022, e202201630.

  • Sidi Zhang, Zhenhua Li, Qingbing Wang*, Qian Liu, Wei Yuan*, Wei Feng and Fuyou Li*, An NIR‐II Photothermally Triggered “Oxygen Bomb” for Hypoxic Tumor Programmed Cascade Therapy, Adv. Mater. 2022, 34, 2201978.

  • Na Wu, Yishuo Sun, Mengya Kong, Xue Lin, Cong Cao, Zhanxian Li, Wei Feng* and Fuyou Li*, Er‐Based Luminescent Nanothermometer to Explore the Real‐Time Temperature of Cells under External Stimuli, Small, 2022, 18, 2107963.

  • Yuxin Liu, Xingjun Zhu, Zheng Wei, Wei Feng, Luoyuan Li, Liyi Ma, Fuyou Li,* and Jing Zhou*, Customized Photothermal Therapy of Subcutaneous Orthotopic Cancer by Multichannel Luminescent Nanocomposites, Adv. Mater. 2021, 33, 2008615.

  • Ming Xu, Jia Liu, Xianlong Su, Qianwen Zhou, Hang Yuan, Yue Wen, Yihang Cheng, Fuyou Li*, Lanthanide-containing persistent luminescence materials with superbright red afterglow and excellent solution processability, Science China Chemistry, 2021, 64, 2125-2133.

  • Xiaochen Qiu, Qianwen Zhou, Xingjun Zhu, Zugen Wu, Wei Feng*, Fuyou Li*, Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique, Nat. Commun., 2020, 11, 4.

  • Yuyang Gu, Zhiyong Guo, Wei Yuan, Mengya Kong, Yulai Liu, Yongtao Liu, Yilin Gao, Wei Feng*, Fan Wang, Jiajia Zhou, Dayong Jin*, Fuyou Li*, High-sensitivity imaging of time-domain near-infrared light transducer, Nat. Photon., 2019, 13, 525.

  • Shengming Cheng, Bin Shen, Wei Yuan, Xiaobo Zhou, Qingyun Liu, Mengya Kong, Yibing Shi, Pengyuan Yang, Wei Feng*, and Fuyou Li*, Time-Gated Ratiometric Detection with the Same Working Wavelength to Minimize the Interferences from Photon Attenuation for Accurate in Vivo Detection, ACS Central Sci., 2019, 5, 299.

  • Ming Xu, Xianmei Zou, Qianqian Su, Wei Yuan, Cong Cao, Qiuhong Wang, Xingjun Zhu, Wei Feng*, Fuyou Li*, Ratiometric Nanothermometer in Vivo Based on Triplet-Sensitized Upconversion, Nat. Commun., 2018, 9,2698.

  • Xingjun Zhu, Jiachang Li, Xiaochen Qiu, Yi Liu, Wei Feng*, Fuyou Li*, Upconversion Nanocomposite for Programming Combination Cancer Therapy by Precise Control of Microscopic Temperature, Nat. Commun., 2018, 9, 2176

  • Jihye Park, Ming Xu, Fuyou Li*, Hong-Cai Zhou*, 3D Long-Range Triplet Migration in a Water-Stable Metal–Organic Framework for Upconversion-Based Ultralow-Power in Vivo Imaging, J. Am. Chem. Soc., 2018, 140, 5493-5499.

  • Xingjun Zhu§, Wei Feng§, Jian Chang, Yan-Wen Tan, Jiachang Li, Min Chen, Yun Sun & Fuyou Li*, Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature, Nat. Commun., 2016, 7, 10437.

  • Yi Liu, Qianqian Su, Min Chen, Yi Dong, Yibing Shi, Wei Feng, Zhi-Ying Wu, Fuyou Li*, Near-Infrared Upconversion Chemodosimeter for in Vivo Detection of Cu2+ in Wilson Disease, Adv. Mater., 2016. 28, 6625–6630.

  • Yuhao Li, YunSun, Jiachang Li, Qianqian Su, Wei Yuan, Yu Dai, Chunmiao Han, Qiuhong Wang, Wei Feng*, Fuyou Li *, Ultrasensitive Near-Infrared Fluorescence-Enhanced Probe for In Vivo Nitroreductase Imaging, J. Am. Chem. Soc., 2015, 137 (19), 6407–6416.

  • Jing Zhou, Qian Liu, Wei Feng, Yun Sun, Fuyou Li*, Upconversion Luminescent Materials: Advances and Applications, Chem. Rev., 2015, 115, 395−465.

  • Qian Liu, Wei Feng, Tianshe Yang, Tao Yi, Fuyou Li*, Upconversion Luminescence imaging of cells and small-animals, Nat. Protoc., 2013, 8(10), 2033-2044.

  • Yuming Yang, Qiang Zhao, Wei Feng, Fuyou Li*, Luminescent Chemodosimeters for Bioimaging, Chem. Rev., 2013, 113, 192-270.

  • Wei Feng, Chunmiao Han, Fuyou Li*, Upconversion-Nanophosphor-Based Functional Nanocomposites, Adv. Mater., 2013, 25(37), 5287–5303.

  • Zhen Jiang,| Ming Xu,| Fuyou Li*, Yanlei Yu*, Red-light Controllable Liquid-Crystal Soft Actuators via Low-power Excited Upconversion Based on Triplet-Triplet Annihilation, J. Am. Chem. Soc., 2013, 135, 16446-16453.

  • Yi Liu, Min Chen, Tianye Cao, Yun Sun, Chunyan Li, Qian Liu, Tianshe Yang, Liming Yao, Wei Feng, Fuyou Li*, A Cyanine-modified Nanosystem for in vivo Upconversion Luminescence Bioimaging of Methylmercury, J. Am. Chem. Soc., 2013, 135, 9869-9876.

  • Qian Liu, Baoru Yin, Tianshe Yang, Yongchao Yang, Zhen Shen, Ping Yao, Fuyou Li*, A general strategy for biocompatible, high-effective upconversion nanocapsules based on triplet-triplet annihilation, J. Am. Chem. Soc., 2013, 135, 5029–5037.

  • Yun Sun, Xingjun Zhu, Juanjuan Peng, Fuyou Li*, Core-shell lanthanide upconversion nanophorsphors as four-modal probes for tumor angiogenesis imaging, ACS Nano, 2013, 7 (12), 11290–11300.

  • Qian Liu, Tianshe Yang, Wei Feng, Fuyou Li*, Blue-emissive upconversion nanoparticles for low-power-excited bioimaging in vivo, J. Am. Chem. Soc., 2012, 134 (11), 5390–5397.

  • Chunyan Li, Mengxiao Yu, Yun Sun, Yongquan Wu, Chunhui Huang, Fuyou Li*, A Nonemissive Iridium(III) Complex That Specifically Lights-up the Nuclei of Living Cells, J. Am. Chem. Soc., 2011, 133, 11231–11239.

  • Jinliang Liu, Yi Liu, Qian Liu, Chunyan, Li, Lining Sun, Fuyou Li*, Iridium(III) Complex-Coated Nanosystem for Ratiometric Upconversion Luminescence Bioimaging of Cyanide Anions J. Am. Chem. Soc., 2011, 133, 15276–15279.

  • Wei Wu, Liming Yao, Tianshe Yang, Ruoyuan Yin, Fuyou Li*, Yanlei Yu*, NIR-Light-Induced Deformation of Cross-Linked Liquid-Crystal Polymers Using Upconversion Nanophosphors, J. Am. Chem. Soc., 2011, 133, 15810–15813.

  • Qian Liu, Yun Sun, Tianshe Yang, Wei Feng, Chenguang Li, Fuyou Li*, Sub-10 nm hexagonal lanthanide-doped NaLuF4 upconversion nanocyrstals for super-sensitive bioimaging in vivo, J. Am. Chem. Soc., 2011, 133, 17122–17125.

  • Mengxiao Yu, Fuyou Li,* Zhigang Chen, He Hu, Cheng Zhan, Hong Yang, Chunhui Huang, Laser Scanning Up-Conversion Luminescence Microscopy for Imaging Cells Labeled with Rare-Earth Nanophosphors, Anal. Chem., 2009, 81(3), 930–935.

  • Zhigang Chen, Huili Chen, He Hu, Mengxiao Yu, Fuyou Li,* Qiang Zhang, Zhiguo Zhou, Tao Yi, Chunhui Huang*, Versatile Synthesis Strategy for Carboxylic Acid-functionalized Upconverting Nanophosphors as Biological Labels, J. Am. Chem. Soc., 2008, 130, 3023-3029.

  • Meng Zhang, Mengxiao Yu, Fuyou Li,* Minwei Zhu, Menyu Li, Yanhong Gao, Lei Li, Zhiqiang Liu, Jianping Zhang, Dengqing Zhang, Tao Yi, Chunhui Huang*, A Highly Selective Fluorescence Turn-on Sensor for Cysteine/Homocysteine and Its Application in Bioimaging, J. Am. Chem. Soc., 2007, 129, 10322-10323.