教育背景

• 2004.08-2009.09     纽约大学，化学，博士

• 1999.09-2004.07     中国科学技术大学，应用化学

工作经历

• 2022.1~ : 上海交通大学化学化工学院，研究员

• 2015.6~2021.12：复旦大学生物医学研究院，研究员

• 2009.11~2015.5：耶鲁大学分子生物系，博士后

研究方向

• DNA纳米结构设计、组装与应用；

• 功能核酸的定向进化及生物技术开发；

科研项目

• 国自然基金委创新研究群体，82121002，肿瘤免疫治疗新策略，2022-2026，骨干；

• 科技部重点研发计划，2020YFA0908901，微纳生物机器人的定向合成和诊疗应用（课题一），2020-2025，主持；

• 国自然基金委重大研究计划，91859104，肿瘤演进与诊疗的分子功能可视化研究（培育项目），2019-2021，主持，已结题；

• 国自然国际（地区）合作与交流重大项目，81861138004，靶向治疗类风湿性关节炎的核酸纳米抗体研究，2018-2022，共同主持；

• 国自然基金委面上项目，21673050，DNA纳米骨架的组装及其在生物和材料学中的应用，2017-2020, 主持，已结题；

• 科技部重点研发计划，2016YFC1306400，重大慢性非传染性疾病防控—阿尔茨海默病早期诊断体液标志物研究，2016-2020，子课题负责人，已结题。

代表性论文

独立PI期间

• Qinqin Hu#; Zongxuan Tong#; Ayimukedisi Yalikong#; Li-Ping Ge#; Qiang Shi; Xinyu Du; Pu Wang; Xi-Yu Liu; Wuqiang Zhan; Xia Gao; Di Sun; Tong Fu; Dan Ye; Jie Liu; Chunhai Fan; Yun-Shi Zhong*; Yi-Zhou Jiang*; Hongzhou Gu*. “DNAzyme-Based Faithful Probing-and-Pulldown to Identify Candidate Biomarkers of Low Abundance.” Nature Chemistry 2023, Accepted.

• Mo Zhou#; Tianbin Xu#; Kai Xia; Haiqing Gao; Wei Li; Tingting Zhai; Hongzhou Gu*. “Small DNAs That Specifically and Tightly Bind Transition Metal Ions.” Journal of the American Chemical Society 2023, 145, 16, 8776-8780.
  

• Qiao Zhang#; Kai Xia#; Meng Jiang#; Qingting Li; Weigang Chen; Mingzhe Han; Wei Li; Rongqin Ke; Fei Wang; Yongxing Zhao; Yuehua Liu; Chunhai Fan; Hongzhou Gu*. “Catalytic DNA-Assisted Mass Production of Arbitrary Single-Stranded DNA.” Angewandte Chemie International Edition 2023, e202212011.

• Jin Liu#; Liman Chen#; Tingting Zhai; Wei Li; Yuehua Liu; Hongzhou Gu*. “Programmable Assembly of Amphiphilic DNA through Controlled Cholesterol Stacking.” Journal of the American Chemical Society 2022, 144, 36, 16598-16603.

• Yang Yang#; Zhenyong Wu#; Laurie Wang; Kaifeng Zhou; Kai Xia; Qiancheng Xiong; Longfei Liu; Zhao Zhang; Edwin R Chapman; Yong Xiong; Thomas J Melia; Erdem Karatekin; Hongzhou Gu*; Chenxiang Lin*. “Sorting liposomes of distinct sizes by DNA-brick assisted centrifugation.” Nature Chemistry 2021, 13, 335-342.

• Youli Jia#; Liman Chen#; Jin Liu; Wei Li; Hongzhou Gu*. “DNA Catalyzed Efficient Production of Single-stranded DNA Nanostructurs.” Chem 2021, 7, 4, 959-981.

• Qingting Li; Zongxuan Tong; Yichun Cao; Hongzhou Gu*. “DNAs catalyzing DNA nanoconstruction.” Chem 2021, 7, 10, 2556-2568.

• Canyu Zhang; Qingting Li; Tianbin Xu; Wei Li; Yungang He; Hongzhou Gu*. “New DNA-hydrolyzing DNAs isolated from an ssDNA library carrying a terminal hybridization stem.” Nucleic Acids Research 2021, 49, 11, 6364-6374.

• Xinyu Du#; Xiaoqin Cheng#; Wei Li; Zhilei Ge; Chunjiu Zhong; Chunhai Fan; Hongzhou Gu*. "Engineering allosteric ribozymes to detect thiamine pyrophosphate in whole blood.” Analytical Chemistry 2021, 93, 9, 4277-4284.

• Tianbin Xu#; Canyu Zhang#; Kai Xia; Wei Li; Yichun Cao; Hongzhou Gu*. “Small DNAs that bind nickel(II) specifically and tightly.” Analytical Chemistry 2021, 93, 45, 14912-14917.

• Qingting Li; Shu Zhang; Wei Li; Zhilei Ge; Chunhai Fan; Hongzhou Gu*. “Programming CircLigase catalysis for DNA rings and topologies.” Analytical Chemistry 2021, 93, 3, 1801-1810.

• Dong-Jie Tang#; Xinyu Du#; Qiang Shi#; Jian-Ling Zhang#; Yuan-Ping He; Yan-Miao Chen; Zhenhua Ming; Dan Wang; Wan-Ying Zhong; Yu-Wei Liang; Jin-Yang Liu; Jian-Ming Huang; Yun-Shi Zhong; Hongzhou Gu*; Ji-Liang Tang*. “A SAM-I riboswitch with the ability to sense and respond to uncharged initiator tRNA.” Nature Communications 2020, 11, 2794, 1-11.

• Xinyu Du#; Xin Zhong#; Wei Li; Hua Li*; Hongzhou Gu*. “Retraining and Optimizing DNA-Hydrolyzing Deoxyribozymes for Robust Single- and Multiple-Turnover Activities.” ACS Catalysis 2018, 8, 5996-6005.

博士-博后期间

• Hongzhou Gu; Kazuhiro Furukawa; Zasha Weinberg; Daniel F. Berenson; Ronald R. Breaker. “Small, Highly-active DNAs that Hydrolyze DNA.” Journal of the American Chemical Society 2013, 135, 9121-9129.

• Hongzhou Gu; Ronald R. Breaker. “Production of Single-stranded DNAs by Self-cleavage of Rolling-circle Amplification Products.” BioTechniques 2013, 54, 337-343.

• Hongzhou Gu; Kazuhiro Furukawa; Ronald R. Breaker. “Engineered Allosteric Ribozymes that Sense the Bacterial Second Messenger c-di-GMP.” Analytical Chemistry 2012, 84, 4935-4941.

• Hongzhou Gu; Jie Chao; Shou-Jun Xiao; Nadrian C. Seeman. “A Proximity-Based Programmable DNA Nanoscale Assembly Line.” Nature 2010, 465, 202-205.

• Hongzhou Gu; Wei Yang; Nadrian C. Seeman. “DNA Scissors Device Used to Measure MutS Binding to DNA Mis-Pairs.” Journal of the American Chemical Society 2010, 132, 4352-4357.

• Hongzhou Gu; Jie Chao; Shou-Jun Xiao; Nadrian C. Seeman. “Dynamic Patterning Programmed by DNA Tiles Captured on a DNA Origami Substrate.” Nature Nanotechnology 2009, 4, 245-248.