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沈建磊

博士,长聘教轨副教授,博士生导师

电子邮件:shenjianlei@sjtu.edu.cn

通讯地址:转化医学中心S400,上海交通大学闵行校区

教育背景

  • 2013.09-2016.07     中国科学院上海应用物理研究所,无机化学,博士

  • 2010.09-2013.07   中国科学院上海应用物理研究所,无机化学,硕士

  • 2006.09-2010.07     合肥工业大学,制药工程,学士

工作经历

  • 2022.1~ : 上海交通大学化学化工学院,长聘教轨副教授

  • 2018.10~2021.7:上海交通大学化学化工学院,长聘教轨助理教授

  • 2016.9.11~2018.9:华南理工大学发光材料与器件国家重点实验室,博士后

研究方向

DNA纳米技术编码单分子荧光探针;

药物跨膜递送及膜成像分析;

科研项目

  • 科技部重点研发计划,2020YFA0908104,生物活体材料的应用探索和设计原则凝练,2020-2025,骨干;

  • 国自然青年基金,21904087,基于聚集诱导发光的双模态AIE-ELISA检测方法研究,2020-2022,主持;

  • 上海市青年科技启明星,21QA1404800,寡聚核苷酸功能化原子精细发光探针,2021-2024,主持;

  • 上海市科技创新计划,19ZR1474600,“软”发光纳米粒子的制备及其用于免疫刺激药物载运的研究,2019-2022,主持,已结题;

  • 上海市科技创新计划,20dz1101002,框架核酸存储基元的设计与表征,2020-2022, 主持;

代表性论文

独立PI期间

  • Liang, C.; Chen, J.; Li, M.; Ge, Z.; Fan, C.*; Shen, J.*, Probing the self-assembly process of amphiphilic tetrahedral DNA frameworks. Chemical Communications 2022, 58 (60), 8352-8355.

  • Liang, C.; Chen, J.; Li, M.; Li, Q.; Fan, C.*; Luo, S.*; Shen, J.*, Programming the self-assembly of amphiphilic DNA frameworks for sequential boolean logic functions. Chemical Communications 2022, 58 (63), 8786-8789.

  • Li, Y.; Lu, H.; Qu, Z.; Li, M.; Zheng, H.; Gu, P.; Shi, J.; Li, J.; Li, Q.; Wang, L.; Chen, J.; Fan, C.; Shen, J.*, Phase transferring luminescent gold nanoclusters via single-stranded DNA. Science China-Chemistry 2022, 65 (6), 1212-1220.

  • Feng, L.; Li, J.; Sun, J.; Wang, L.; Fan, C.; Shen, J.*, Recent Advances of DNA Nanostructure-Based Cell Membrane Engineering. Advanced Healthcare Materials 2021, 10 (6).

  • Chen, B.; Huang, Q.; Qu, Z.; Li, C.; Li, Q.; Shi, J.; Fan, C.; Wang, L.; Zuo, X.; Shen, J.*; Li, J.*, Probing Transient DNA Conformation Changes with an Intercalative Fluorescent Excimer. Angewandte Chemie-International Edition 2021, 60 (12), 6624-6630.

  • Gu, P.; Chen, B.; Zhai, T.; Li, Q.; Zuo, X.; Wang, L.; Qin, A.; Zhou, Y.*; Shen, J.*, Immunostimulatory AIE Dots for Live-Cell Imaging and Drug Delivery. ACS Applied Materials & Interfaces 2021, 13 (17), 19660-19667.

博士-博后期间

  • Shen, J.; Liang, L.; Xiao, M.; Xie, X.; Wang, F.; Li, Q.; Ge, Z.; Li, J.; Shi, J.; Wang, L.; Li, L.; Pei, H.; Fan, C., Fractal Nanoplasmonic Labels for Supermultiplex Imaging in Single Cells. Journal of the American Chemical Society 2019, 141 (30), 11938-11946.

  • Shen, J.; Luan, B.; Pei, H.; Yang, Z.; Zuo, X.; Liu, G.; Shi, J.; Wang, L.; Zhou, R.; Cheng, W.; Fan, C., Humidity-Responsive Single-Nanoparticle-Layer Plasmonic Films. Advanced Materials 2017, 29 (35).

  • Shen, J.; Tang, Q.; Li, L.; Li, J.; Zuo, X.; Qu, X.; Pei, H.; Wang, L.; Fan, C., Valence-Engineering of Quantum Dots Using Programmable DNA Scaffolds. Angewandte Chemie-International Edition 2017, 56 (50), 16077-16081.

  • Shen, J.; Xu, L.; Wang, C.; Pei, H.; Tai, R.; Song, S.; Huang, Q.; Fan, C.; Chen, G., Dynamic and Quantitative Control of the DNA-Mediated Growth of Gold Plasmonic Nanostructures. Angewandte Chemie-International Edition 2014, 53 (32), 8338-8342.

  • Shen, J.; Hu, R.; Zhou, T.; Wang, Z.; Zhang, Y.; Li, S.; Gui, C.; Jiang, M.; Qin, A.; Tang, B. Z., Fluorescent Sensor Array for Highly Efficient Microbial Lysate Identification through Competitive Interactions. ACS Sensors 2018, 3 (11), 2218-2222.

  • Shen, J.; Situ, B.; Du, X.; Wang, Z.; Hu, R.; Li, B.; Qin, A.; Tang, B. Z., Aggregation-Induced Emission Luminogen-Based Dual-Mode Enzyme-Linked Immunosorbent Assay for Ultrasensitive Detection of Cancer Biomarkers in a Broad Concentration Range. ACS Sensors 2022, 7 (3), 766-774.

  • Shen, J.; Su, J.; Yan, J.; Zhao, B.; Wang, D.; Wang, S.; Li, K.; Liu, M.; He, Y.; Mathur, S.; Fan, C.; Song, S., Bimetallic nano-mushrooms with DNA-mediated interior nanogaps for high-efficiency SERS signal amplification. Nano Research 2015, 8 (3), 731-742.