宋萍
博士,副教授,博士生导师
电子邮件:songpingsjtu@sjtu.edu.cn
通讯地址:文选医学楼112B,上海交通大学闵行校区
教育背景
2013-2016 中国科学院上海应用物理研究所,无机化学,博士
2010-2013 上海师范大学,硕士,分析化学
工作经历
2021-至今: 上海交通大学生物医学工程学院,长聘教轨副教授
2019-2021:NuProbe Inc (USA), 高级研究科学家(兼职),癌症诊断
2017-2021:莱斯大学,高级研究科学家,生物工程
2016-2017:莱斯大学,博士后,生物工程
研究方向
DNA数据存储;
可编程核酸探针的设计及癌症诊断的应用;
科研项目
国自然基金委面上项目,BC0820174,多重置换高通量放大cfDNA中TP53全外显子突变检测研究,2022-2025, 主持;
科技部重点研发计划,2021YFF1200300,基于大规模可寻址可控催化原理的 DNA 合成新技术研发,2021-2024,课题骨干;
海外优青计划。
代表性论文
Ping Song#, Lucia Ruojia Wu#, Yan Helen Yan, Jinny X. Zhang, Tianqing Chu, Lawrence N. Kwong, Abhijit A. Patel, and David Yu Zhang. "Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics." Nature Biomedical Engineering 2022, 1-14.
Nina G Xie#, Michael X Wang#, Ping Song, Shiqi Mao, Yifan Wang, Yuxia Yang, Junfeng Luo, Shengxiang Ren*, David Yu Zhang*. Designing highly multiplex PCR primer sets with Simulated Annealing Design using Dimer Likelihood Estimation (SADDLE). Nature Communications 2022, 13, 1881.
Ping Song, Sherry X. Chen, Yan Helen Yan, Alessandro Pinto, Lauren Y. Cheng, Peng Dai, Abhijit A. Patel, and David Yu Zhang. "Selective multiplexed enrichment for the detection and quantitation of low-fraction DNA variants via low-depth sequencing." Nature Biomedical Engineering 2021, 5, 690-701.
Thirunavukarasu, Deepak, Lauren Y. Cheng, Ping Song, Sherry X. Chen, Mitesh J. Borad, Lawrence Kwong, Phillip James, Daniel J. Turner, and David Yu Zhang. "Oncogene Concatenated Enriched Amplicon Nanopore Sequencing for rapid, accurate, and affordable somatic mutation detection." Genome biology 2021, 22, 1-17.
Ping Song, Juwen Shen, Dekai Ye, Baijun Dong, Fei Wang, Hao Pei, Jianbang Wang et al. "Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework." Nature communications 2020, 11, 1-10.
Ye, Dekai#, Min Li#, Tingting Zhai#, Ping Song#, Lu Song, Hua Wang, Xiuhai Mao et al. "Encapsulation and release of living tumor cells using hydrogels with the hybridization chain reaction." Nature Protocols 2020, 15, 2163-2185.
Romano, Gabriele, Pei-Ling Chen, Ping Song, Jennifer L. McQuade, Roger J. Liang, Mingguang Liu, Whijae Roh et al. "A preexisting rare PIK3CAE545K subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling." Cancer discovery 2018, 8, 556-567.
Ping Song, Dekai Ye, Xiaolei Zuo, Jiang Li, Jianbang Wang, Huajie Liu, Michael T. Hwang et al. "DNA hydrogel with aptamer-toehold-based recognition, cloaking, and decloaking of circulating tumor cells for live cell analysis." Nano letters 2017, 17, 5193-5198.
Lin, Meihua, Ping Song, Guobao Zhou, Xiaolei Zuo, Ali Aldalbahi, Xiaoding Lou, Jiye Shi, and Chunhai Fan. "Electrochemical detection of nucleic acids, proteins, small molecules and cells using a DNA-nanostructure-based universal biosensing platform." Nature Protocols 2016, 11, 1244-1263.
Ping Song, Min Li, Juwen Shen, Hao Pei, Jie Chao, Shao Su, Ali Aldalbahi et al. "Dynamic modulation of DNA hybridization using allosteric DNA tetrahedral nanostructures." Analytical chemistry 2016, 88, 8043-8049.
Zhu, Dan#, Ping Song#, Juwen Shen, Shao Su, Jie Chao, Ali Aldalbahi, Ziang Zhou et al. "PolyA-mediated DNA assembly on gold nanoparticles for thermodynamically favorable and rapid hybridization analysis." Analytical chemistry 2016, 88, 4949-4954.