教育背景

• 2000.9-2005.6   中科院有机所, 有机化学, 博士

• 1996.9-2000.6   南京大学, 化学, 学士

工作经历

• 2016.3~ : 上海交通大学化学化工学院, 副教授

• 2013.12~2016.2：美国WARP DRIVE BIO生物技术公司, 化学生物学系，研究科学家

• 2012.4~2013.11：美国纪念斯隆凯特琳癌症研究中心, 化学生物学系，研究科学家。

• 2008.4~2012.3：美国纪念斯隆凯特琳癌症研究中心，博士后

• 2005.10~2008.3：美国Burnham研究所，博士后

研究方向

• 复杂糖基化蛋白的合成及功能研究；

• 蛋白质修饰以及相关化学生物学研究；

科研项目

• 国家杰出青年科学基金,22225701,蛋白质的精准化学修饰与合成及生物学功能研究, 2023-01-01 至 2027-12-31,在研,主持

• 上海市科学技术委员会基础研究特区计划，21TQ1400200，糖蛋白的精准编辑与定向组装，2021-至今；骨干；

• 国家自然科学基金面上项目，22077080，几丁质结合蛋白CBP21及其类似物的半合成与活性评价，2021-2024，主持；

• 上海交通大学医工交叉项目，YG2020YQ14，突刺糖蛋白糖基化结合域合成以及特异性抗体筛选与宿主靶点的鉴定，2020，主持，已结题；

• 国家自然科学基金重大研究计划培育项目，91753102，精准高效合成糖基化白细胞介素15，2018-2020，主持，已结题；

• 国家自然科学基金面上项目，21672146，化学合成干扰素伽玛，2017-2020，主持，已结题；

• 上海市自然科学基金基础研究计划，17JC1405300，白介素2的化学合成，2017-2020，参与，已结题；

代表性论文

独立PI期间

• Zhao, J.; Liu, J.; Liu, X.; Ye, F.; Wang, S.; Wang, P*, Semi-synthesis of interleukin-1α via expressed threonine ligation and native chemical ligation-desulfurization. Tetrahedron Lett. 2022,104, 154024

• Zheng, M.; Yin, H.; Wang S.; Wang, P.*, Stereoselective Synthesis of β-thiolated Aryl Amino Acids. Synthesis 2022, 54, A-I.

• Chen, X.;  Luo, X.; Wang, P.*, Electrochemical-induced Radical Allylation via the Fragmentation of Alkyl 1,4-Dihydropyridines. Tetrahedron Lett. 2022, 91, 153646.

• Luo, X.; Feng, Q.; Wang, P.*, Radical Addition of Hydroxy Quinazolines and Alkylation of Quinones via the Electro-induced Homolysis of 4-Alkyl-1,4-dihydropyridines. Synthesis. 2022, 54, 2696–2706

• Wang, S.; Zhou, Q.; Li, Y.; Wei, B.; Liu, X.; Zhao, J.; Ye, F.; Zhou, Z.; Ding, B.; Wang, P.*. Quinoline-based photolabile protection strategy facilitates efficient protein assembly. J. Am. Chem. Soc. 2022, 144, 1232-1242.

• Zhao, J.; Wang, P.*, et. al. Revealing functional significance of interleukin-2 glycoproteoforms enabled by expressed serine ligation. Chin. J. Chem. 2022, 40, 787-793.

• Wang, S.; Zhou, Q.; Zhang, X.; Wang, P.*, Site-Selective Itaconation of Complex Peptides by Photoredox Catalysis. Angew. Chem. Int. Ed. 2022, 61(5):e202111388.

• Chen, X.; Wang, P.*, Facile Access to C-Glycosyl Amino Acids and Peptides via Ni-Catalyzed Reductive Hydroglycosylation of Alkynes. Chin. J. Org. Chem. 2021, 41, 4517-4518.

• Luo, X.; Wang, P.*, Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4 Acyl1,4-dihydropyridine. Org. Lett. 2021, 23, 4960-4965.

• Wang, S.; Zhou, Q.; Chen, X.; Luo, R.-H.; Li, Y.; Liu, X.; Yang, L.-M.; Zheng, Y.-T.*; Wang, P.*, Modification of N-Terminal α-Amine of Proteins via Biomimetic ortho-quinone-mediated Oxidation. Nat. Commun. 2021, 12:2257.

• Ye, F.; Zhao, J.; Xu, P.; Liu, X.; Yu, J.; Shangguan, W.; Liu, J.; Luo, X.; Li, C.; Ying, T.; Wang, J.; Yu, B.; Wang, P.*, Synthetic Homogeneous Glycoforms of the SARS-CoV-2 Spike Receptor-Binding Domain Reveals Different Binding Profiles of Monoclonal Antibodies. Angew. Chem. Int. Ed. 2021, 60, 12904-12910.

• Li, Y.; Liu, J.; Zhou, Q.; Zhao, J.; Wang, P.*, The preparation of peptide selenoesters from their corresponding acyl hydrazides. Chin. J. Chem. 2021, 39, 1861-1866.

• Chen, X.;  Luo, X.;  Wang, K.;  Liang, F.; Wang, P.*, Late-Stage Alkylation of N-Containing Heteroarenes Enabled by Homolysis of Alkyl-1,4-dihydropyridines under Blue LED Irradiation. Synlett 2021, 32, 733–737.

• Yin, H.;  Zheng, M.;  Chen, H.;  Wang, S.;  Zhou, Q.;  Zhang, Q.; Wang, P.*, Stereoselective and Divergent Construction of β-Thiolated/Selenolated Amino Acids via Photoredox-Catalyzed Asymmetric Giese Reaction. J. Am. Chem. Soc. 2020, 142, 14201-14209.

• Chen, X.; Luo, X.; Peng, X.; Guo, J.; Zai, J.; Wang, P.*, Catalyst-Free Decarboxylation of Carboxylic Acids and Deoxygenation of Alcohols by Electro-Induced Radical Formation. Chem. Eur. J. 2020, 26, 3226- 3230.

• Lu, D.;  Wang, S.;  Yin, H.;  Chu, F.*;  Wei, Q.*; Wang, P.*, Rapid Assembly of Oligosaccharides by Using a Hydrophobic Tag-Assisted Liquid-Phase Method. Synlett 2020, 31, 1163-1166.

• Lu, D.;  Yin, H.;  Wang, S.;  Tang, F.;  Huang, W.; Wang, P.*, Chemical Synthesis of the Homogeneous Granulocyte-Macrophage Colony-Stimulating Factor Through Se-Auxiliary-Mediated Ligation. J. Org. Chem. 2020, 85, 1652-1660.

• Chen, X.;  Ye, F.;  Luo, X.;  Liu, X.;  Zhao, J.;  Wang, S.;  Zhou, Q.;  Chen, G.*; Wang, P.*, Histidine-Specific Peptide Modification via Visible-Light-Promoted C–H Alkylation. J. Am. Chem. Soc. 2019, 141, 18230-18237.

• Liu, X.;  Liu, J.;  Wu, Z.;  Chen, L.;  Wang, S.; Wang, P.*, Photo-cleavable purification/protection handle assisted synthesis of giant modified proteins with tandem repeats. Chem. Sci. 2019, 10, 8694-8700.

• Wang, K.;  Chen, X.;  Peng, X.;  Wang, P.*; Liang, F.*, A highly selective H/D exchange reaction of 1,4-dihydropyridines. Org. Biomol. Chem. 2019, 17, 3845-3852.

• Wang, S.;  Thopate, Y. A.;  Zhou, Q.; Wang, P.*, Chemical Protein Synthesis by Native Chemical Ligation and Variations Thereof. Chin. J. Chem. 2019, 37, 1181-1193.

• Ye, J.;  Xia, H.;  Sun, N.;  Liu, C.-C.;  Sheng, A.;  Chi, L.;  Liu, X.-W.;  Gu, G.;  Wang, S.-Q.;  Zhao, J.; Wang, P.;  Xiao, M.;  Wang, F.; Cao, H., Reprogramming the enzymatic assembly line for site-specific fucosylation. Nat. Catal. 2019, 2, 514-522.

• Yin, H.;  Lu, D.;  Wang, S.; Wang, P.*, Development of Powerful Auxiliary-Mediated Ligation To Facilitate Rapid Protein Assembly. Org. Lett. 2019, 21, 5138-5142.

• Luo, H.;  Yin, H.;  Tang, C.;  Wang, P.*; Liang, F.*, Synthesis of cyclic peptide reniochalistatin E and conformational isomers. Chin. Chem. Lett. 2018, 29, 1143-1146.

博士-博后期间

• Wang, P.; Dong, S.; Shieh, J.-H.; Peguero, E.; Hendrickson, R.; Moore, M. A. S.; Danishefsky, S. J., Erythropoietin Derived by Chemical Synthesis. Science 2013, 342 (6164), 1357-1360.

• Wilson, R. M.; Dong, S.; Wang, P.; Danishefsky, S. J., The Winding Pathway to Erythropoietin Along the Chemistry–Biology Frontier: A Success At Last. Angew. Chem. Int. Ed. 2013, 52 (30), 7646-7665.

• Yang, X.; Wang, P.; Yu, B., Tackling the Challenges in the Total Synthesis of Landomycin A. Chem. Rec. 2013, 13 (1), 70-84.

• Wang, P.; Dong, S.; Brailsford, J. A.; Iyer, K.; Townsend, S. D.; Zhang, Q.; Hendrickson, R. C.; Shieh, J.; Moore, M. A. S.; Danishefsky, S. J., At Last: Erythropoietin as a Single Glycoform. Angew. Chem. Int. Ed. 2012, 51 (46), 11576-11584.

• Wang, P.; Aussedat, B.; Vohra, Y.; Danishefsky, S. J., An Advance in the Chemical Synthesis of Homogeneous N-Linked Glycopolypeptides by Convergent Aspartylation. Angew. Chem. Int. Ed. 2012, 51 (46), 11571-11575.

• Wilson, R. M.; Stockdill, J. L.; Wu, X.; Li, X.; Vadola, P. A.; Park, P. K.; Wang, P.; Danishefsky, S. J., A Fascinating Journey into History: Exploration of the World of Isonitriles En Route to Complex Amides. Angew. Chem. Int. Ed. 2012, 51 (12), 2834-2848.

• Shibata, T. K.; Matsumura, F.; Wang, P.; Yu, S.; Chou, C.-C.; Khoo, K.-H.; Kitayama, K.; Akama, T. O.; Sugihara, K.; Kanayama, N.; Kojima-Aikawa, K.; Seeberger, P. H.; Fukuda, M.; Suzuki, A.; Aoki, D.; Fukuda, M. N., Identification of Mono- and Disulfated N-Acetyl-lactosaminyl Oligosaccharide Structures as Epitopes Specifically Recognized by Humanized Monoclonal Antibody HMOCC-1 Raised against Ovarian Cancer. J. Biol. Chem. 2012, 287 (9), 6592-6602.

• Wang, P.; Li, X.; Zhu, J.; Chen, J.; Yuan, Y.; Wu, X.; Danishefsky, S. J., Encouraging Progress in the ω-Aspartylation of Complex Oligosaccharides as a General Route to β-N-Linked Glycopolypeptides. J. Am. Chem. Soc. 2011, 133 (5), 1597-1602.

• Wang, P.; Danishefsky, S. J., Promising General Solution to the Problem of Ligating Peptides and Glycopeptides. J. Am. Chem. Soc. 2010, 132 (47), 17045-17051.

• Wu, X.; Stockdill, J. L.; Wang, P.; Danishefsky, S. J., Total Synthesis of Cyclosporine: Access to N-Methylated Peptides via Isonitrile Coupling Reactions. J. Am. Chem. Soc. 2010, 132 (12), 4098-4100.

• Chen, J.; Wang, P.; Zhu, J.; Wan, Q.; Danishefsky, S. J., A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides. Tetrahedron 2010, 66 (13), 2277-2283.

• Wang, P.; Zhu, J.; Yuan, Y.; Danishefsky, S. J., Total Synthesis of the 2,6-Sialylated Immunoglobulin G Glycopeptide Fragment in Homogeneous Form. J. Am. Chem. Soc. 2009, 131 (46), 16669-16671.

• Lee, H.; Wang, P.; Hoshino, H.; Ito, Y.; Kobayashi, M.; Nakayama, J.; Seeberger, P. H.; Fukuda, M., α1,4GlcNAc-capped mucin-type O-glycan inhibits cholesterol α-glucosyltransferase from Helicobacter pylori and suppresses H. pylori growth. Glycobiology 2008, 18 (7), 549-558.

• Wang, P.; Lee, H.; Fukuda, M.; Seeberger, P. H., One-pot synthesis of a pentasaccharide with antibiotic activity against Helicobacter pylori. Chem. Commun. 2007, 38 (19), 1963-1965.

• Lee, H.; Kobayashi, M.; Wang, P.; Nakayama, J.; Seeberger, P. H.; Fukuda, M., Expression cloning of cholesterol α-glucosyltransferase, a unique enzyme that can be inhibited by natural antibiotic gastric mucin O-glycans, from Helicobacter pylori. Biochem. Biophys. Res. Commun. 2006, 349 (4), 1235-1241.

• Wang, P.; Zhang, Z.; Yu, B., Total Synthesis of CRM646-A and -B, Two Fungal Glucuronides with Potent Heparinase Inhibition Activities. J. Org. Chem. 2005, 70 (22), 8884-8889.

• Yu, B.; Wang, P., Efficient Synthesis of the He xasaccharide Fragment of Landomycin A:  Using Phenyl 2,3-O-Thionocarbonyl-1-thioglycosides as 2-Deoxy-β-glycoside Precursors. Org. Lett. 2002, 4 (11), 1919-1922.

专著

• Yin, H.; Zhou, Q.; Wang, S.; Wang, P.*, Methods in Molecular Biology，Chemical Protein Synthesis, Chapter 9, ”General solution to the preparation of ꞵ-thiolated/selenolated amino acids via visible light catalyzed asymmetric Giese reaction”, in press.

• 何春茂，王平，李学臣，董甦伟，刘磊. 《合成科学按照战略报告2021-2035》，第十五章 蛋白质的合成. In press.

专利

• Jeffrey V. Ravetch, Andrew Pincetic, Ping Wang, Samuel J. Danishefsky, Human DC-SIGN binding peptides derived from IgG1 Fc fragment. PCT Int. Appl. 2013, WO 2013095973 A1 20130627.

• Samuel J. Danishefsky, Ping Wang, Suwei Dong, Malcolm A. Moore, Jaehung Shieh, John A. Brailsford,. Homogenous and fully glycosylated human erythropoietin. PCT Int. Appl. (2013), WO 2013166053 A2 20131107.

• 王平；陈小平；叶发荣；通过可见光促进的C-H烷基化修饰的含组氨酸的多肽类化合物及其制备方法，2022-1-10, 中国, 201910758444.4 （专利）

• 王平；尹红礼；一种合成β-S氨基酸的方法, 2022-2-11, 中国, 201911100880.9 （专利）