English
张欢
博士，长聘教轨副教授，课题组长，博士生导师
电子邮件：zhang_huan@sjtu.edu.cn
通讯地址：农业与生物学院创新楼B-411，上海交通大学闵行校区
教育背景
2009.08-2014.09 中国科学院大学，无机化学，博士
2005.09-2009.07 鲁东大学，材料化学，学士
工作经历
2022.7~ 至今: 上海交通大学农业与生物学院，长聘教轨副教授
2020.9~2022.6：暨南大学化学与材料学院，预聘教授
2017.2~2020.8：加州大学伯克利分校化学与生物工程系，博士后
2014.9~2017.1：中国科学院上海高等研究院，助理研究员
研究方向
框架核酸的精密设计和可控自组装；
纳米探针开发及生物传感和生物成像应用；
纳米技术介导的植物体系基因编辑、功能分子递送和疾病治疗。
科研项目
广东省自然科学基金面上项目，2022A1515011839，功能DNA纳米材料与植物相互作用分析及生物应用研究，2022-2024，主持，在研；
国自然基金委青年项目，21605153，DNA纳米技术调控的新型芯片体系开发及其microRNA检测研究，2017-2019, 主持，已结题；
国家重点研发计划，2016YFC0100600，基于随机采样的快速超分辨荧光成像技术研究及其样机实现，2016-2018，项目骨干，已结题。
代表性论文
Huan Zhang#, Natalie S Goh#, Jeffrey Wang, Gozde S Demirer, Salwan Butrus, So-Jung Park, Markita Landry*. Nanoparticle Cellular Internalization is Not Required for RNA Delivery to Mature Plant Leaves. Nature Nanotechnology, 2022, 17, 197-205.
Huan Zhang#, Yuhong Cao#, Dawei Xu, Natalie S Goh, Gozde S Demirer, Stefano Cestellos-Blanco, Yuan Chen, Markita P. Landry*, Peidong Yang*. Gold Nanocluster Mediated Delivery of siRNA to Intact Plant Cells for Efficient Gene Knockdown. Nano Letters, 2021, 21, 5859–5866.
Huan Zhang#, Honglu Zhang#, Gozde S. Demirer, Eduardo González-Grandío, Chunhai Fan and Markita P. Landry*. Engineering DNA nanostructures for siRNA delivery in plants. Nature Protocols, 2020, 15, 3064-3087.
Huan Zhang#, Gozde S. Demirer#, Honglu Zhang#, Tianzheng Ye, Natalie S. Goh, Abhishek J. Aditham, Francis J. Cunningham, Chunhai Fan and Markita P. Landry*. DNA Nanostructures Coordinate Gene Silencing in Mature Plants. PNAS, 2019,116, 15:7543-7548.
Gozde S. Demirer#, Huan Zhang#, Natalie S. Goh, Markita P. Landry*. Carbon nanotube-mediated DNA delivery without transgene integration in intact plants. Nature Protocols, 2019, 14, 2954-2971.
Honglu Zhang#, Yu Wang#, Huan Zhang#, Xiaoguo Liu#, Antony Lee, Jie Chao, Huajie Liu, Jiang li, Jiye Shi, Lihua Wang, Lianhui Wang, Xiaoyu Cao, Carlos Bustamante, Zhongqun Tian*, Chunhai Fan*. Programming chain-growth co-polymerization of DNA hairpin tiles for in-vitro hierarchical supramolecular organization. Nature Communications, 2019, 10, 1006 (1-11).
Gozde S. Demirer, Huan Zhang, Juliana L. Matos, Natalie Goh, Francis Cunningham, Younghun Sung, Roger Chang, Abhishek J. Aditham, Linda Chio, Myeong-Je Cho, Brian Staskawicz and Markita P. Landry*. High Aspect Ratio Nanomaterials Enable Delivery of Functional Genetic Material Without Transgenic DNA Integration in Mature Plants. Nature Nanotechnology, 2019, 14, 456-464.
Gozde S. Demirer, Huan Zhang, Natalie S. Goh and Markita P. Landry. Nanotubes effectively deliver siRNA to intact plant cells and protect siRNA against nuclease degradation. Science Advances, 2020, 6, eaaz0495.
Huan Zhang#*, Xinxin Liu#, Chunxiu Zhang, Yi Xu, Jing Su, Xiaoliang Lu, Jiye Shi, Lihua Wang, Markita P. Landry, Ying Zhu, Min Lv*, Xianqiang Mi*. A DNA tetrahedral structure-mediated ultrasensitive fluorescent microarray platform for nucleic acid test. Sensors & Actuators: B. Chemical, 2020, 321, 12853.
Lu Wang#, Huan Zhang#, Chenguang Wang, Yi Xu, Jing Su, Xiao Wang, Xinxin Liu, Dezhi Feng, Lihua Wang, Xiaolei Zuo, Jiye Shi, Zhilei Ge*, Chunhai Fan, Xianqiang Mi*. Poly-adenine-mediated spherical nucleic acids for strand displacement-based DNA/RNA detection. Biosensors and Bioelectronics, 2019, 127, 85-91.
Huan Zhang#, Honglu Zhang#, Ali Aldalbahi, Xiaolei Zuo, Chunhai Fan, Xianqiang Mi*. Fluorescent Biosensors Enabled by Graphene and Graphene Oxide. Biosensors and Bioelectronics, 2017, 89, 96-106.
