English
左小磊
博士，研究员，博士生导师
电子邮件：zuoxiaolei@sjtu.edu.cn
通讯地址：上海交通大学医学院附属仁济医院（东院）17号楼1718室
教育背景
2005.04-2008.01 中国科学院上海应用物理研究所，无机化学，博士
2002.08-2005.03 中南大学，分析化学，硕士
1998.08-2002.07 中南大学，分析化学，学士
工作经历
2017.10~现在, 上海交通大学, 医学院分子医学研究院, 博士生导师，研究员
2012.10~2017.10, 中国科学院上海应用物理研究所, 物理生物学研究室, 研究员
2010.12~2012.10, 美国洛斯阿拉莫斯国家实验室, 博士后
2008.10~2010.11, 加州大学圣巴巴拉分校, 博士后
研究方向
框架核酸、DNA存储
科研项目
国家自然科学基金杰出青年科学基金项目， 22025404，化学测量学，主持。
国家重点研发计划，生物与信息融合（BT与IT融合）重点专项， 2021YFF1200300，基于大规模可寻址可控催化原理的DNA合成新技术研发，主持。
国家自然科学基金优秀青年科学基金项目， 21422508，分析化学，主持。
国家自然科学基金面上项目， 31470960，纳米电化学逻辑器件及其在前列腺癌早期诊断中的应用，主持。
代表性论文
Li, Fan; Li, Jiang; Dong, Baijun*; Wang, Fei; Fan, Chunhai; Zuo, Xiaolei*; DNA Nanotechnology-Empowered Nanoscopic Imaging of Biomolecules. Chemical Society Reviews 2021, 50 (9), 5650-5667.
Li, Min#; Yin, Fangfei#; Song, Lu#; Mao, Xiuhai; Li, Fan; Fan, Chunhai; Zuo, Xiaolei*; Xia, Qiang*; Nucleic Acid Tests for Clinical Translation. Chemical Reviews 2021, 121 (17), 10469-10558.
Li, Fengqin; Mao, Xiuhai; Li, Fan; Li, Min; Shen, Jianlei; Ge, Zhilei; Fan, Chunhai; Zuo, Xiaolei*; Ultrafast DNA Sensors with DNA Framework-Bridged Hybridization Reactions. Journal of the American Chemical Society 2020, 142 (22), 9975-9981.
Song, Ping#; Shen, Juwen#; Ye, Dekai#; Dong, Baijun; Wang, Fei; Pei, Hao; Wang, Jianbang; Shi, Jiye; Wang, Lihua; Xue, Wei; Huang, Yiran; Huang, Gang; Zuo, Xiaolei*； Fan, Chunhai*; Programming Bulk Enzyme Heterojunctions for Biosensor Development with Tetrahedral DNA Framework. Nature Communications 2020, 11 (1), 838.
Ye, Dekai#; Li, Min#; Zhai, Tingting#; Song, Ping#; Song, Lu; Wang, Hua; Mao, Xiuhai; Wang, Fei; Zhang, Xueli; Ge, Zhilei; Shi, Jiye; Wang, Lihua; Fan, Chunhai; Li, Qian*; Zuo, Xiaolei*; Encapsulation and Release of Living Tumor Cells Using Hydrogels with the Hybridization Chain Reaction. Nature Protocols 2020, 15 (7), 2163-2185.
Zhang, Yueyue#; Mao, Xiuhai#; Li, Fan; Li, Min; Jing, Xinxin; Ge, Zhilei; Wang, Lihua; Liu, Kai; Zhang, Hongjie; Fan, Chunhai; Zuo, Xiaolei*; Nanoparticle-Assisted Alignment of Carbon Nanotubes on DNA Origami. Angewandte Chemie International Edition 2020, 59 (12), 4892-4896.
Li, Min#; Ding, Hongming#; Lin, Meihua; Yin, Fangfei; Song, Lu; Mao, Xiuhai; Li, Fan; Ge, Zhilei; Wang, Lihua; Zuo, Xiaolei*; Ma, Yuqiang*; Fan, Chunhai; DNA Framework-Programmed Cell Capture Via Topology-Engineered Receptor–Ligand Interactions. Journal of the American Chemical Society 2019, 141 (47), 18910-18915.
Zhang, Yueyue#; Li, Fan#; Li, Min; Mao, Xiuhai; Jing, Xinxin; Liu, Xiaoguo; Li, Qian; Li, Jiang; Wang, Lihua; Fan, Chunhai; Zuo, Xiaolei*; Encoding Carbon Nanotubes with Tubular Nucleic Acids for Information Storage. Journal of the American Chemical Society 2019, 141 (44), 17861-17866.
Liu, Qi#; Ge, Zhilei#; Mao, Xiuhai; Zhou, Guobao; Zuo, Xiaolei*; Shen, Juwen; Shi, Jiye; Li, Jiang; Wang, Lihua; Chen, Xiaoqing; Fan, Chunhai; Valency-Controlled Framework Nucleic Acid Signal Amplifiers. Angewandte Chemie International Edition 2018, 57 (24), 7131-7135.
Shen, Jianlei#; Tang, Qian#; Li, Li#; Li, Jiang; Zuo, Xiaolei*; Qu, Xiangmeng; Pei, Hao; Wang, Lihua; Fan, Chunhai; Valence-Engineering of Quantum Dots Using Programmable DNA Scaffolds. Angewandte Chemie International Edition 2017, 56 (50), 16077-16081.
Zuo, Xiaolei; Fan, Chunhai; Chen, Hong-Yuan; Biosensing: Crispr-Powered Diagnostics. Nature Biomedical Engineering 2017, 1 (6), 0091.
Lin, Meihua; Song, Ping; Zhou, Guobao; Zuo, Xiaolei*; Aldalbahi, Ali; Lou, Xiaoding; Shi, Jiye; Fan, Chunhai; Electrochemical Detection of Nucleic Acids, Proteins, Small Molecules and Cells Using a DNA-Nanostructure-Based Universal Biosensing Platform. Nature Protocols 2016, 11, 1244-1263.
Zhu, Dan; Pei, Hao; Yao, Guangbao; Wang, Lihua; Su, Shao; Chao, Jie; Wang, Lianhui; Aldalbahi, Ali; Song, Shiping; Shi, Jiye; Hu, Jun; Fan, Chunhai; Zuo, Xiaolei*; A Surface-Confined Proton-Driven DNA Pump Using a Dynamic 3d DNA Scaffold. Advanced Materials 2016, 28 (32), 6860-6865.
Lin, Meihua; Wang, Jingjing; Zhou, Guobao; Wang, Jianbang; Wu, Na; Lu, Jianxin; Gao, Jimin; Chen, Xiaoqing; Shi, Jiye; Zuo, Xiaolei*; Fan, Chunhai*; Programmable Engineering of a Biosensing Interface with Tetrahedral DNA Nanostructures for Ultrasensitive DNA Detection. Angewandte Chemie International Edition 2015, 54 (7), 2151-2155.
Shen, Juwen#; Li, Yuebin#; Gu, Haoshuang; Xia, Fan*; Zuo, Xiaolei*; Recent Development of Sandwich Assay Based on the Nanobiotechnologies for Proteins, Nucleic Acids, Small Molecules, and Ions. Chemical Reviews 2014, 114 (15), 7631-7677.
Lin, Meihua; Pei, Hao; Yang, Fan; Fan, Chunhai*; Zuo, Xiaolei*; Applications of Gold Nanoparticles in the Detection and Identification of Infectious Diseases and Biothreats. Advanced Materials 2013, 25 (25), 3490-3496.
Zuo, Xiaolei#; Xia, Fan#; Xiao, Yi*; Plaxco, Kevin W.*; Sensitive and Selective Amplified Fluorescence DNA Detection Based on Exonuclease Iii-Aided Target Recycling. Journal of the American Chemical Society 2010, 132 (6), 1816-1818.
Zuo, Xiaolei; Xiao, Yi; Plaxco, Kevin W.*; High Specificity, Electrochemical Sandwich Assays Based on Single Aptamer Sequences and Suitable for the Direct Detection of Small-Molecule Targets in Blood and Other Complex Matrices. Journal of the American Chemical Society 2009, 131 (20), 6944-6945.
Zuo, Xiaolei; Song, Shiping; Zhang, Jiong; Pan, Dun; Wang, Lihua; Fan, Chunhai*; A Target-Responsive Electrochemical Aptamer Switch (Treas) for Reagentless Detection of Nanomolar ATP. Journal of the American Chemical Society 2007, 129 (5), 1042-1043.
